In the quest for discovering relevant unknowns, an all inclusive acquisition strategy has proven most appropriate. DIA offers the benefit of seeing all ions, all the time without prejudice. Chromatography optimised for resolution has proven most valuable to maximise DIA acquisition. What if, speed optimised chromatography came with little compromise. This talk focuses on novel advances in DIA acquisition strategies, SONAR and HDMSe for reducing sample complexity and getting the most out of metabolomic sample analysis.